Is The Diagnosis of Carcinoma with Neuroendocrine Features of The Breast Possible in Fine-Needle Aspiration Specimens?

Several previous studies focused on the ability of fine-needle aspiration cytology (FNAC) to diagnose carcinomas with neuroendocrine features (CNF). A pre-operative cytological diagnosis of malignancy was made in all seven CNF cases in the present study. However, we failed to accurately subtype most of these breast carcinoma cases. Five cases were reported as invasive carcinoma of no special type, one as intracystic carcinoma, and only one as neuroendocrine DCIS suggested. The expectation that FNAC methods can reliably make similar diagnoses as a histopathological diagnosis on morphological grounds alone may be overly optimistic at present. The accuracy of a FNAC diagnosis in the management of CNF depends on multiple approaches including the immunohistochemical staining of surgical specimens.